Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants.

ABSTRACT:

Background

Infants born by caesarean section or receiving antibiotics are at increased risk of developing metabolic, inflammatory and immunological diseases, potentially due to disruption of normal gut microbiota at a critical developmental time window. We investigated whether probiotic supplementation could ameliorate the effects of antibiotic use or caesarean birth on infant microbiota in a double blind, placebo-controlled randomized clinical trial. Mothers were given a multispecies probiotic, consisting of Bifidobacterium breve Bb99 (Bp99 2 × 10⁸ cfu) Propionibacterium freundenreichii subsp. shermanii JS (2 × 10⁹cfu), Lactobacillus rhamnosus Lc705 (5 × 10⁹ cfu) and Lactobacillus rhamnosus GG (5 × 10⁹ cfu) (N = 168 breastfed and 31 form

SUBMITTER: Korpela K 

PROVIDER: S-EPMC6192119 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature