EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish.

ABSTRACT:

Background

The blood filtering organ in zebrafish embryos is the pronephros, which consists of two functional nephrons. Segmentation of a nephron into different domains is essential for its function and is well conserved among vertebrates. Zebrafish has been extensively used as a model to understand nephron segmentation during development. Here, we have identified EF-hand domain containing 2 (Efhc2) as a novel component of genetic programme regulating nephron segmentation in zebrafish. Human EFHC2 is a protein with one predicted calcium-binding EF-hand motif and three DM10 domains, whose function is unknown. EFHC2 has been implicated in several brain-related genetic diseases like Turner syndrome and juvenile myoclonic epilepsy. However, there is limited information on its normal ph

SUBMITTER: Barrodia P 

PROVIDER: S-EPMC6192171 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature