Estrogen receptor β is associated with expression of cancer associated genes and survival in ovarian cancer.

ABSTRACT:

Background

In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytoplasmic ERβ in ovarian cancer and correlated it with expression of ovarian cancer markers CA125, CEA and CA72-4, steroid hormone receptors ERα and PR, cancer-associated genes EGFR, p53, HER2 and proliferation marker Ki-67. Additionally we examined to what extent expression of ERβ and the other proteins affects survival of ovarian cancer patients.

Methods

We established a tissue microarray from 171 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins.

Results

Nuclear ERβ was detected in 47.31% of the ovarian cancer

SUBMITTER: Schuler-Toprak S 

PROVIDER: S-EPMC6192185 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature