Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.

ABSTRACT:

Background

In the REMoxTB study of 4-month treatment-shortening regimens containing moxifloxacin compared to the standard 6-month regimen for tuberculosis, the proportion of unfavourable outcomes for women was similar in all study arms, but men had more frequent unfavourable outcomes (bacteriologically or clinically defined failure or relapse within 18 months after randomisation) on the shortened moxifloxacin-containing regimens. The reason for this gender disparity in treatment outcome is poorly understood.

Methods

The gender differences in baseline variables were calculated, as was time to smear and culture conversion and Kaplan-Meier plots were constructed. In post hoc exploratory analyses, multivariable logistic regression modelling and an observed case analysis were use

SUBMITTER: Murphy ME 

PROVIDER: S-EPMC6192317 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature