A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages.

ABSTRACT:

Background

Plasmodium vivax is the most geographically widespread of the human malaria parasites, causing 50,000 to 100,000 deaths annually. Plasmodium vivax parasites have the unique feature of forming dormant liver stages (hypnozoites) that can reactivate weeks or months after a parasite-infected mosquito bite, leading to new symptomatic blood stage infections. Efforts to eliminate P. vivax malaria likely will need to target the persistent hypnozoites in the liver. Therefore, research on P. vivax liver stages necessitates a marker for clearly distinguishing between actively replicating parasites and dormant hypnozoites. Hypnozoites possess a densely fluorescent prominence in the parasitophorous vacuole membrane (PVM) when stained with antibodies against the PVM-resident protein U

SUBMITTER: Schafer C 

PROVIDER: S-EPMC6192329 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature