Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis.

ABSTRACT:

Objectives

Restless legs syndrome (RLS) can lead to severe clinical consequences, thus negatively impacts on patients' overall health and quality of life. Nevertheless, the pathophysiology of RLS is still unclear, resulting in underestimate, incorrect, or ignored diagnosis and in limited management and treatment. The aim of this study was to compare the plasma proteome of RLS patients and healthy controls, in the search of diagnostic biomarkers related to the disease severity.

Materials and methods

Two-dimensional gel electrophoresis coupled with liquid chromatography-mass spectrometry was employed to analyze plasma samples of 34 patients with primary RLS, divided into two subgroups according to the disease severity: MMS group (mild-moderate symptoms) and HS group (severe an

SUBMITTER: Bellei E 

PROVIDER: S-EPMC6192389 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature