Systematic analysis of genetic variants in patients with essential tremor.

ABSTRACT:

Background

Essential tremor (ET), a prevalent neurological disorder, is featured by postural and kinetic tremors in upper limbs. Studies of twins and families indicate an important role for genetic factors in ET development. There are substantial overlaps between ET and Parkinson's disease (PD). The aim of this study was to examine the possible roles of genetic variants in ET development.

Methods

A total of 200 Han Chinese ET patients and 432 ethnically matched normal controls were enrolled, and genetic analysis of 23 variants in 15 genes was performed.

Results

Genotypic and allelic frequencies of the melanocortin 1 receptor gene (MC1R) variant rs34090186 showed statistically significant differences in ET patients and controls (p = 0.027 and 0.028, odds ratio = 2.789

SUBMITTER: Yuan L 

PROVIDER: S-EPMC6192404 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature