Impaired white matter integrity between premotor cortex and basal ganglia in writer's cramp.

ABSTRACT:

Introduction

Writer's cramp (WC) as a focal hand dystonia is characterized by abnormal postures of the hand during writing. Impaired inhibition and maladaptive plasticity in circuits linking the basal ganglia and sensorimotor cortices have been described. In particular, a dysfunction of lateral premotor cortices has been associated with impaired motor control in WC. We applied diffusion tensor imaging to identify changes in white matter connectivity between premotor regions and important cortical and subcortical structures.

Methods

Whole brain white matter tracts were reconstructed in 18 right-handed WC patients and 18 matched controls, using probabilistic fiber tracking. We restricted our analyses to left-hemispheric fibers between the middle frontal gyrus (MFG) and basal g

SUBMITTER: Berndt M 

PROVIDER: S-EPMC6192408 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature