Gene Mapping and Gene-Set Analysis for Milk Fever Incidence in Holstein Dairy Cattle.

ABSTRACT: Milk fever is an important metabolic disorder that affects dairy cows around parturition. It is associated with a breakdown in the mechanisms of calcium homeostasis, resulting in very low blood calcium levels (hypocalcemia). The main objective of this study was to dissect the genetic basis underlying milk fever incidence in Holstein cattle. Data consisted of 31.6 k producer-recorded lactation incidence records from 15.3 k cows. The analysis included a whole-genome scan and a subsequent gene-set analysis in order to reveal individual genes, genetic mechanisms and biological pathways implicated in the incidence of periparturient hypocalcemia. The association analysis identified at least eight different genomic regions that explain considerable amounts of additive genetic variance for milk fe

SUBMITTER: Pacheco HA 

PROVIDER: S-EPMC6192420 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature