Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs.

ABSTRACT: Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that often results in burst release and short release duration. This work reports a design of composite clay hydrogels, which simultaneously achieve a spectrum of mechanical, storage, and drug loading/releasing properties to address the critical needs from translational perspectives. The clay nanoparticles provide large surface areas to adsorb biological drugs, and assemble into microparticles that are physically trapped within and toughen hydrogel networks. The composite hydrogels demonstrate feasibility of storage, and extended release of large quantit

SUBMITTER: Li J 

PROVIDER: S-EPMC6192424 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature