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Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4⁺ T Cell-Independent CD8⁺ T-Cell Response Against Unconjugated Protein Antigen.

ABSTRACT: There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim, we formulated class-B synthetic oligodeoxynucleotide containing unmethylated cytosine-guanine motifs (CpG-ODN) with a nanostructure (Coa-ASC16 or coagel) formed by self-assembly of 6-0-ascorbyl palmitate ester. Our previous results demonstrated that mice immunized with ovalbumin (OVA) and CpG-ODN formulated with Coa-ASC16 (OVA/CpG-ODN/Coa-ASC16) elicited strong antibodies (IgG1 and IgG2a) and Th1/Th17 cellular responses without toxic systemic effects. These responses were superior to those induced by a solution of OVA with CpG-ODN or OVA/CpG-ODN formulated with aluminum salts. In this study, we investigated

SUBMITTER: Chiodetti AL

PROVIDER: S-EPMC6192457 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4⁺ T Cell-Independent CD8⁺ T-Cell Response Against Unconjugated Protein Antigen.

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Dataset Information

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4⁺ T Cell-Independent CD8⁺ T-Cell Response Against Unconjugated Protein Antigen.