When two are better than one: Bilateral mesial temporal lobe contributions associated with better vocabulary skills in children and adolescents.

ABSTRACT: This study considered the involvement of the mesial temporal lobe (MTL) in language and verbal memory functions in healthy children and adolescents. We investigated 30 healthy, right-handed children and adolescents, aged 7-16, with a fMRI language paradigm and a comprehensive cognitive test battery. We found significant MTL activations during language fMRI in all participants; 63% of them had left lateralized MTL activations, 20% exhibited right MTL lateralization, and 17% showed bilateral MTL involvement during the fMRI language paradigm. Group analyses demonstrated a strong negative correlation between the lateralization of MTL activations and language functions. Specifically, children with less lateralized MTL activation showed significantly better vocabulary skills. These findings sugg

SUBMITTER: Bartha-Doering L 

PROVIDER: S-EPMC6192511 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature