Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer.

ABSTRACT:

Background

Physical activity is associated with a lower risk of disease recurrence among colon cancer patients. Circulating tumor cells (CTC) are prognostic of disease recurrence among stage I-III colon cancer patients. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in CTCs.

Methods

Participants included 23 stage I-III colon cancer patients randomized into one of three groups: usual-care control, 150 min∙wk-1 of aerobic exercise (low-dose), and 300 min∙wk-1 of aerobic exercise (high-dose) for six months. CTCs from venous blood were quantified in a blinded fashion using an established microfluidic antibody-mediated capture device. Poisson regression models estimated the logarithmic counts of CTCs.

Results

SUBMITTER: Brown JC 

PROVIDER: S-EPMC6192582 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature