Functional conservation of sequence determinants at rapidly evolving regulatory regions across mammals.

ABSTRACT: Recent advances in epigenomics have made it possible to map genome-wide regulatory regions using empirical methods. Subsequent comparative epigenomic studies have revealed that regulatory regions diverge rapidly between genome of different species, and that the divergence is more pronounced in enhancers than in promoters. To understand genomic changes underlying these patterns, we investigated if we can identify specific sequence fragments that are over-enriched in regulatory regions, thus potentially contributing to regulatory functions of such regions. Here we report numerous sequence fragments that are statistically over-enriched in enhancers and promoters of different mammals (which we refer to as 'sequence determinants'). Interestingly, the degree of statistical enrichment, which pres

SUBMITTER: Huh I 

PROVIDER: S-EPMC6192654 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature