Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users. We estimated heritability due to common variants (h²_SNP), and performed a GWAS of the three phenotypes. Replicatio

SUBMITTER: Dunn EC 

PROVIDER: S-EPMC6192675 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature