Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.

ABSTRACT: Influenza viruses represent a serious threat to human health. Although our research group has previously demonstrated the antiviral and anti‑inflammatory activities of eleutheroside B1, a detailed explanation of the mechanism by which it is effective against the influenza virus remains to be elucidated. In the present study, the transcriptomic responses of influenza A virus‑infected lung epithelial cells (A549) treated with eleutheroside B1 were investigated using high‑throughput RNA sequencing, and potential targets were identified using a molecular docking technique, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) assay, and DNA methylation analysis. The transcriptomic data revealed that there are 1,871 differentially expressed genes (DEGs) between the cells infect

SUBMITTER: Yan W 

PROVIDER: S-EPMC6192727 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature