Radiotherapy with radical cystectomy for bladder cancer: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Muscle-invasive bladder cancer (MIBC) is associated with high recurrence and mortality rates. The role of radiotherapy as an adjunct to radical cystectomy is not well-defined. We sought to evaluate the efficacy and safety of radiotherapy preoperatively or postoperatively for patients with MIBC receiving cystectomy compared to cystectomy alone. The primary outcome was overall survival. The secondary outcome was adverse effects.

Methods

MEDLINE, EMBASE, and CENTRAL were searched on August 30, 2016 for randomized controlled trials (RCTs) of patients undergoing cystectomy for bladder cancer. A control group receiving cystectomy alone and an intervention group with radiotherapy and cystectomy were required. The Jadad score was used to assess for bias. Fifteen studies

SUBMITTER: Mcalpine K 

PROVIDER: S-EPMC6192740 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature