Sequence analysis of the Pre-S gene in chronic asymptomatic HBV carriers with low-level HBsAg.

ABSTRACT: In a hepatitis B virus (HBV)‑infected population, persistently low expression levels of serum HBV serum antigen (HBsAg) are present, particularly in chronic asymptomatic HBV carriers (ASCs). The present study sequenced the HBV Pre‑S gene, and aimed to elucidate its features in ASCs with low HBsAg expression compared with in the established HBV Pre‑S reference gene sequences from ASCs with high HBsAg expression. A total of 1,308 ASCs were grouped according to HBsAg serum levels (cut‑off value, 10 IU/ml), and clinical characteristics were analyzed in detail. The HBV Pre‑S gene was sequenced in 276 ASCs with low‑level HBsAg; in addition, 100 of the remaining 1,032 ASCs with high‑level HBsAg were randomly selected for HBV Pre‑S gene sequencing on the basis of age matching with the low‑level HB

SUBMITTER: Wang T 

PROVIDER: S-EPMC6192773 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature