Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines.

ABSTRACT: OBJECTIVES:Psychosocial stress is postulated to hasten senescence in part by accelerating the shortening of telomere length (TL). One pathway through which this may happen is via increasing inflammation and innate immune system activation-a pathway which recent studies suggest acts more strongly for those who grew up in low microbial environments. Thus, we hypothesized that: (1) Psychosocial stress will be inversely associated with TL, (2) early life microbial environments will predict TL, and (3) microbial environments will moderate the association between psychosocial stress and TL. METHODS:We utilized data from the Cebu Longitudinal Health and Nutrition Survey based in the Philippines (N = 1410). We determined early life microbial environments by season of birth and exposure to animal f

SUBMITTER: Tennyson RL 

PROVIDER: S-EPMC6192840 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature