Managing local-regional failure in children with high-risk neuroblastoma: A single institution experience.

ABSTRACT:

Background

Intensification of systemic therapy for high-risk neuroblastoma (HRNB) has resulted in improved local control and overall survival (OS) leaving potential for de-escalation of primary site radiotherapy. The utility of primary site de-escalation should be evaluated in the context of potential for successful local-regional salvage. We evaluated salvage strategies and outcomes in patients with HRNB with local-regional recurrence as a component of first failure.

Methods

Twenty of 89 patients with HRNB experienced local-regional recurrence as a component of first relapse after chemotherapy, radiotherapy, surgery, and stem cell transplant from 1997 to 2013. We reviewed salvage therapy strategies and disease control, and report on the impact of local therapy as salvage fo

SUBMITTER: Dove AP 

PROVIDER: S-EPMC6192847 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature