Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b.

ABSTRACT: KCNK2 is a 2 pore domain potassium channel involved in maintaining cellular membrane resting potentials. Although KCNK2 is regarded as a mechanosensitive ion channel, it can also be gated chemically. Previous research indicates that KCNK2 expression is particularly enriched in neuronal and cardiac tissues. In this respect, KCNK2 plays an important role in neuroprotection and has also been linked to cardiac arrhythmias. KCNK2 has subsequently become an attractive pharmacologic target for developing preventative/curative strategies for neuro/cardio pathophysiological conditions. Zebrafish represent an important in vivo model for rapidly analysing pharmacological compounds. We therefore sought to identify and characterise zebrafish kcnk2 to allow this model system to be incorporated into ther

SUBMITTER: Nasr N 

PROVIDER: S-EPMC6192994 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature