Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron.

ABSTRACT: How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors: reversal initiation and feeding suppression in response to different concentrations of quinine. Low concentrations of quinine are decoded in AIB by a low-threshold, fast-inactivation glutamate receptor GLR-1 and translated into reversal initiation. In contrast, high concentrations of quinine are decoded by a high-threshold, slow-inactivation glutamate receptor GLR-5 in AIB. After activation, GLR-5 evokes sustained Ca²⁺ release from the inositol 1,4,5-trisphosphate (IP₃)-sensitive Ca²⁺ stores and triggers neuropeptide secretion, which

SUBMITTER: Zou W 

PROVIDER: S-EPMC6193023 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature