Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy.

ABSTRACT: Selective delivery of photosensitizers to mitochondria of cancer cells can enhance the efficacy of photodynamic therapy (PDT). Though cationic Ru-based photosensitizers accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application in PDT. We recently discovered X-ray based cancer therapy by nanoscale metal-organic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic therapy (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT. Constructed from Ru-based photosensitizers, the cationic framework exhibits strong mitochondria-targeting property. Upon X-ray irradiation, Hf-DBB-Ru efficiently generates hydroxyl radicals from the Hf₆ SBUs and singlet oxygen from the DBB-Ru ph

SUBMITTER: Ni K 

PROVIDER: S-EPMC6193046 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature