Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish.

ABSTRACT: In teleosts, the onset of puberty in females is marked by the appearance of the first wave of pre-vitellogenic (PV) follicles from the pool of primary growth (PG) follicles (follicle activation) in the ovary during sexual maturation. To understand the mechanisms underlying follicle activation and therefore puberty onset, we undertook this transcriptomic study to investigate gene expression profiles in the event. Our analysis revealed a total of 2,027 up-regulated and 859 down-regulated genes during the PG-PV transition. Gene Ontology (GO) analysis showed that in addition to basic cellular functions such as gene transcription, cell differentiation, and cell migration, other biological processes such as steroidogenesis, cell signaling and angiogenesis were also enriched in up-regulated genes

SUBMITTER: Zhu B 

PROVIDER: S-EPMC6193065 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature