Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation.

ABSTRACT: Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor histocompatibility antigens (mHA). The mHA presented on the HLA class I and II molecules and the ensuing T cell response to these antigens results in graft vs. host disease. In this paper, results of a whole exome sequencing study are presented, with resulting alloreactive polymorphic peptides and their HLA class I and HLA class II (DRB1) binding affinity quantified. Large libraries of potentially alloreactive recipient peptides binding both sets of molecules were identified, with HLA-DRB1 generally presenting a greater number of peptides. These results are

SUBMITTER: Salman A 

PROVIDER: S-EPMC6193078 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature