Functional Connectivity in Multiple Sclerosis: Recent Findings and Future Directions.

ABSTRACT: Multiple sclerosis is a debilitating disorder resulting from scattered lesions in the central nervous system. Because of the high variability of the lesion patterns between patients, it is difficult to relate existing biomarkers to symptoms and their progression. The scattered nature of lesions in multiple sclerosis offers itself to be studied through the lens of network analyses. Recent research into multiple sclerosis has taken such a network approach by making use of functional connectivity. In this review, we briefly introduce measures of functional connectivity and how to compute them. We then identify several common observations resulting from this approach: (a) high likelihood of altered connectivity in deep-gray matter regions, (b) decrease of brain modularity, (c) hemispheric asym

SUBMITTER: Tahedl M 

PROVIDER: S-EPMC6193088 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature