The Leptomeninges Produce Prostaglandin D₂ Involved in Sleep Regulation in Mice.

ABSTRACT: Injection of nanomolar amounts of prostaglandin D₂ (PGD₂) into the rat brain has dose and time-dependent somnogenic effects, and the PGD₂-induced sleep is indistinguishable from physiologic sleep. Sleep-inducing PGD₂ is produced in the brain by lipocalin-type PGD₂ synthase (LPGDS). Three potential intracranial sources of LPGDS have been identified: oligodendrocytes, choroid plexus, and leptomeninges. We aimed at the identification of the site of synthesis of somnogenic PGD₂ and therefore, generated a transgenic mouse line with the LPGDS gene amenable to conditional deletion using Cre recombinase (flox-LPGDS mouse). To identify the cell type responsible for producing somnogenic PGD₂, we engineered animals lacking L

SUBMITTER: Cherasse Y 

PROVIDER: S-EPMC6193105 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature