Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors.

ABSTRACT: γ-aminobutyric acid (GABA) pathways play an important role in neuronal circuitry formation during early postnatal development. Our previous studies revealed an increased risk for adverse neurodevelopmental consequences in animals exposed to benzodiazepines, which enhance GABA inhibition via GABA_A receptors. We reported that administration of the benzodiazepine clonazepam (CZP) during postnatal days 7-11 resulted in permanent behavioral alterations. However, the mechanisms underlying these changes are unknown. We hypothesized that early CZP exposure modifies development of glutamatergic receptors and their composition due to the tight developmental link between GABAergic functions and maturation of glutamatergic signaling. These changes may alter excitatory synapses, as well as n

SUBMITTER: Kubova H 

PROVIDER: S-EPMC6193113 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature