Chromosome evolution at the origin of the ancestral vertebrate genome.

ABSTRACT:

Background

It has been proposed that more than 450 million years ago, two successive whole genome duplications took place in a marine chordate lineage before leading to the common ancestor of vertebrates. A precise reconstruction of these founding events would provide a framework to better understand the impact of these early whole genome duplications on extant vertebrates.

Results

We reconstruct the evolution of chromosomes at the beginning of vertebrate evolution. We first compare 61 extant animal genomes to reconstruct the highly contiguous order of genes in a 326-million-year-old ancestral Amniota genome. In this genome, we establish a well-supported list of duplicated genes originating from the two whole genome duplications to identify tetrads of duplicated chromosomes.

SUBMITTER: Sacerdot C 

PROVIDER: S-EPMC6193309 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature