Gene Expression Profile Signature of Aggressive Waldenstrom Macroglobulinemia with Chromosome 6q Deletion.

ABSTRACT:

Background

Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoma. Clinically, chromosome 6q deletion (6q del) including loss of the B lymphocyte-induced maturation protein 1 gene (BLIMP-1) is reported to be associated with poor prognosis. However, it remains unclear how the underlying biological mechanism contributes to the aggressiveness of WM with 6q del.

Methods

Here, we conducted oligonucleotide microarray analysis to clarify the differences in gene expression between WM with and without 6q del. Gene ontology (GO) analysis was performed to identify the main pathways underlying differences in gene expression. Eight bone marrow formalin-fixed paraffin-embedded samples of WM were processed for interphase fluorescence in situ hybridization analysis, and thre

SUBMITTER: Sekiguchi N 

PROVIDER: S-EPMC6193339 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature