Probiotic Product Enhances Susceptibility of Mice to Cryptosporidiosis.

ABSTRACT: Cryptosporidiosis, a leading cause of diarrhea among infants, is caused by apicomplexan parasites classified in the genus Cryptosporidium The lack of effective drugs is motivating research to develop alternative treatments. With this aim, the impact of probiotics on the course of cryptosporidiosis was investigated. The native intestinal microbiota of specific pathogen-free immunosuppressed mice was initially depleted with orally administered antibiotics. A commercially available probiotic product intended for human consumption was subsequently added to the drinking water. Mice were infected with Cryptosporidium parvum oocysts. On average, mice treated with the probiotic product developed more severe infections. The probiotics significantly altered the fecal microbiota, but no

SUBMITTER: Oliveira BCM 

PROVIDER: S-EPMC6193388 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature