The Hierarchical Modular Structure of HER2+ Breast Cancer Network.

ABSTRACT: HER2-enriched breast cancer is a complex disease characterized by the overexpression of the ERBB2 amplicon. While the effects of this genomic aberration on the pathology have been studied, genome-wide deregulation patterns in this subtype of cancer are also observed. A novel approach to the study of this malignant neoplasy is the use of transcriptional networks. These networks generally exhibit modular structures, which in turn may be associated to biological processes. This modular regulation of biological functions may also exhibit a hierarchical structure, with deeper levels of modular organization accounting for more specific functional regulation. In this work, we identified the most probable (maximum likelihood) model of the hierarchical modular structure of the HER2-enriched transcr

SUBMITTER: Alcala-Corona SA 

PROVIDER: S-EPMC6193406 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature