Rutin as A Novel c-Met Inhibitory Lead for The Control of Triple Negative Breast Malignancies.

ABSTRACT: Triple negative breast cancer (TNBC) has high metastatic and mortality potential and lacks effective and selective therapeutic options. Aberrant dysregulation of the receptor tyrosine kinase c-Met promotes TNBC progression, motility and survival and therefore considered a valid therapeutic target. Among various identified anticancer agents, plant polyphenols (PPs) including flavonoids, have been shown to be safe and proven for their antitumor activity through modulating diverse macromolecular targets. This study reports the bioassay-guided identification of the common flavonol glycoside rutin as breast cancer cell proliferation, migration and invasion inhibitor. The cell free Z'-LYTE kinase assay, Western blot and in silico docking experiments uncovered, for the first time, c-Met kinase as

SUBMITTER: Elsayed HE 

PROVIDER: S-EPMC6193555 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature