GPSuc: Global Prediction of Generic and Species-specific Succinylation Sites by aggregating multiple sequence features.

ABSTRACT: Lysine succinylation is one of the dominant post-translational modification of the protein that contributes to many biological processes including cell cycle, growth and signal transduction pathways. Identification of succinylation sites is an important step for understanding the function of proteins. The complicated sequence patterns of protein succinylation revealed by proteomic studies highlight the necessity of developing effective species-specific in silico strategies for global prediction succinylation sites. Here we have developed the generic and nine species-specific succinylation site classifiers through aggregating multiple complementary features. We optimized the consecutive features using the Wilcoxon-rank feature selection scheme. The final feature vectors were trained by a ra

SUBMITTER: Hasan MM 

PROVIDER: S-EPMC6193575 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature