Sensitivity of joint contagiousness and susceptibility-based dynamic optimal control strategies for HIV prevention.

ABSTRACT: Predicting the population-level effects of an infectious disease intervention that incorporate multiple modes of intervention is complicated by the joint non-linear dynamics of both infection transmission and the intervention itself. In this paper, we consider the sensitivity of Dynamic Optimal Control Profiles (DOCPs) for the optimal joint investment in both a contagiousness and susceptibility-based control of HIV to bio-behavioral, economic, and programmatic assumptions. The DOCP is calculated using recently developed numerical algorithms that allow controls to be represented by a set of piecewise constant functions that maintain a constant yearly budget. Our transmission model assumes multiple stages of HIV infection corresponding to acute and chronic infection and both within- and betw

SUBMITTER: Bulla I 

PROVIDER: S-EPMC6193630 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature