Prognostic value of ErbB2/HER2 in human meningiomas.

ABSTRACT:

Introduction

Among clinical challenges regarding human meningiomas is their propensity to recur even in cases with benign histology. Reliable biomarkers that can identify these cases are therefore highly desired. ErbB2/HER2 status is important in the medical management of patients with various human malignancies, whereas its clinical relevance in human meningiomas is ambiguous. For this reason, we wanted to investigate the expression of intra- and extracellular domains of ErbB2/HER2 as well as the level of activated receptor in these tumors. Further, we wanted to elucidate any clinicopathological associations to antibody expression and if gene amplification was present.

Methods

In total, 186 human meningiomas of all malignancy grades were included in the study, 163 of these

SUBMITTER: Arnli MB 

PROVIDER: S-EPMC6193666 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature