Subgroup identification in clinical trials via the predicted individual treatment effect.

ABSTRACT: Identifying subgroups of treatment responders through the different phases of clinical trials has the potential to increase success in drug development. Recent developments in subgroup analysis consider subgroups that are defined in terms of the predicted individual treatment effect, i.e. the difference between the predicted outcome under treatment and the predicted outcome under control for each individual, which in turn may depend on multiple biomarkers. In this work, we study the properties of different modelling strategies to estimate the predicted individual treatment effect. We explore linear models and compare different estimation methods, such as maximum likelihood and the Lasso with and without randomized response. For the latter, we implement confidence intervals based on the sel

SUBMITTER: Ballarini NM 

PROVIDER: S-EPMC6193713 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature