Strength and stability of EEG functional connectivity predict treatment response in infants with epileptic spasms.

ABSTRACT: OBJECTIVE:Epileptic spasms (ES) are associated with pathological neuronal networks, which may underlie characteristic EEG patterns such as hypsarrhythmia. Here we evaluate EEG functional connectivity as a quantitative marker of treatment response, in comparison to classic visual EEG features. METHODS:We retrospectively identified 21 ES patients and 21 healthy controls. EEG data recorded before treatment and after ≥10 days of treatment underwent blinded visual assessment, and functional connectivity was measured using cross-correlation techniques. Short-term treatment response and long-term outcome data were collected. RESULTS:Subjects with ES had stronger, more stable functional networks than controls. After treatment initiation, all responders (defined by cessation of spasms) exhibited de

SUBMITTER: Shrey DW 

PROVIDER: S-EPMC6193760 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature