Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine.

ABSTRACT: Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the neuropeptide calcitonin gene-related peptide (CGRP) or its receptor to prevent migraine. Calcitonin gene-related peptide is believed to contribute to trigeminal nerve hypersensitivity and photosensitivity in migraine, but a direct role in pain associated with migraine has not been established. In this study, we report that peripherally administered CGRP can act in a light-independent manner to produce spontaneous pain in mice that is manifested as a facial grimace. As an objective validation of t

SUBMITTER: Rea BJ 

PROVIDER: S-EPMC6193822 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature