Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy.

ABSTRACT: Multiple recent pharmacological clinical trials in neuropathic pain have failed to show beneficial effect of drugs with previously demonstrated efficacy, and estimates of drug efficacy seems to have decreased with accumulation of newer trials. However, this has not been systematically assessed. Here, we analyze time-dependent changes in estimated treatment effect size in pharmacological trials together with factors that may contribute to decreases in estimated effect size. This study is a secondary analysis of data from a previous published NeuPSIG systematic review and meta-analysis, updated to include studies published up till March 2017. We included double-blind, randomized, placebo-controlled trials examining the effect of drugs for which we had made strong or weak recommendations for

SUBMITTER: Finnerup NB 

PROVIDER: S-EPMC6193835 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature