RNA Oncoimmune Phenotyping of HPV-Positive p16-Positive Oropharyngeal Squamous Cell Carcinomas by Nodal Status.

ABSTRACT:

Importance

Clinical trials that deintensify treatment for patients with suspected human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) use p16 expression to identify HPV-mediated tumors and guide treatment. While p16 staining has a strong correlation with good outcomes, approximately 12% of p16-positive patients have recurrent disease. Biomarkers that reveal tumor-specific characteristics, such as nodal involvement, may change therapy decisions.

Objective

To assess whether if a tumor-specific genetic signature exists for node-negative vs node-positive HPV 16-positive/p16-positive OPSCCs.

Design, setting, and participants

This was a retrospective cohort study with randomized case selection for p16 OPSCCs undertaken at a university-based, te

SUBMITTER: Stepp WH 

PROVIDER: S-EPMC6193859 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature