Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

ABSTRACT:

Background

Heart failure (HF) is a complex disease with a rising prevalence despite advances in treatment. Protein phosphatase 1 (PP1) has long been implicated in HF pathogenesis, but its exact role is both unclear and controversial. Most previous studies measured only the PP1 catalytic subunit (PP1c) without investigating its diverse set of interactors, which confer localization and substrate specificity to the holoenzyme. In this study, we define the PP1 interactome in cardiac tissue and test the hypothesis that this interactome becomes rearranged during HF progression at the level of specific PP1c interactors.

Methods

Mice were subjected to transverse aortic constriction and grouped on the basis of ejection fraction into sham, hypertrophy, moderate HF (ejection fraction,

SUBMITTER: Chiang DY 

PROVIDER: S-EPMC6193872 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature