Outpacing the pneumococcus: Antibody dynamics in the first few days following pneumococcal capsular antigen stimulation.

ABSTRACT: Children in developing countries are frequently exposed to the pneumococcus, but few develop invasive pneumococcal disease (IPD). We test the hypothesis that natural variation exists in the rapidity of IgG responses following exposure to pneumococcal polysaccharides, and that these differences are sufficiently great to affect susceptibility to and outcome of IPD. We recruited children aged 24-36 months, who had recovered from IPD, and age-matched healthy controls and vaccinated them with 1 dose of the 23-valent PPV to mimic natural exposure. We collected serum samples after vaccination and analysed the dynamics of anti-polysaccharide antibody responses to several capsular antigens. Mean IgG response times to different serotypes were 6.4-7.3 days, with standard deviations of 0.9-1.85 days,

SUBMITTER: Kimaro Mlacha SZ 

PROVIDER: S-EPMC6193966 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature