Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice.

ABSTRACT: Type 1 diabetes (T1D) is a progressive autoimmune disease in which the insulin-producing beta cells are destroyed by auto-reactive T cells. Recent studies suggest that microbiota are closely associated with disease development. We studied gut, oral and vaginal microbiota longitudinally in non-obese diabetic (NOD) mice. We showed that the composition of microbiota is very different at the different mucosal sites and between young and adult mice. Gut microbiota are more diverse than oral or vaginal microbiota and the changes were more evident in the mice before and after onset of diabetes. Using alpha-diversity, Gram-positive/Gram-negative ratio as well as the relative abundance of Bacteroidetes and Erysipelotrichaceae in the gut microbiota, at 8 weeks of age, we formulated a predictive algo

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6193974 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature