In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species.

ABSTRACT: Helicobacter (H.) pylori is an important risk factor for gastric malignancies worldwide. Its outer membrane proteome takes an important role in colonization of the human gastric mucosa. However, in zoonotic non-H. pylori helicobacters (NHPHs) also associated with human gastric disease, the composition of the outer membrane (OM) proteome and its relative contribution to disease remain largely unknown. By means of a comprehensive survey of the diversity and distribution of predicted outer membrane proteins (OMPs) identified in all known gastric Helicobacter species with fully annotated genome sequences, we found genus- and species-specific families known or thought to be implicated in virulence. Hop adhesins, part of the Helicobacter-specific family 13 (Hop, Hor and Hom) were restricted to t

SUBMITTER: Bauwens E 

PROVIDER: S-EPMC6194013 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature