Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability.

ABSTRACT: Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the "edge" between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation tr

SUBMITTER: Kembro JM 

PROVIDER: S-EPMC6194025 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature