Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC6194050 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181018 1
Oncolytic virotherapy is a promising therapeutic strategy that uses replication-competent viruses to selectively destroy malignancies. However, the therapeutic effect of certain oncolytic viruses (OVs) varies among cancer patients. Thus, it is necessary to overcome resistance to OVs through rationally designed combination strategies. Here, through an anticancer drug screening, we show that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to OV M1 and improves therapeutic ...[more]