A discrete organoplatinum(II) metallacage as a multimodality theranostic platform for cancer photochemotherapy.

ABSTRACT: Photodynamic therapy is an effective alternative to traditional treatments due to its minimally invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug resistance. However, it is still challenging to design photosensitizers with high singlet oxygen (¹O₂) quantum yields (QY) due to severe aggregation of the hydrophobic photosensitizers. Herein, we developed a discrete organoplatinum(II) metallacage using therapeutic cis-(PEt₃)₂Pt(OTf)₂ as the building block to improve the ¹O₂ QY, thus achieving synergistic anticancer efficacy. The metallacage-loaded nanoparticles (MNPs) with tri-modality imaging capability allow precise diagnosis of tumor and real-time monitoring the delivery, biodi

SUBMITTER: Yu G 

PROVIDER: S-EPMC6194061 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature