Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity.

ABSTRACT: Three copper(ii) complexes, [Cu(L1)(NO₃)₂] (C1), [Cu(L2)Cl₂] (C2) and [Cu(L2)SO₄]₂·H₂O (C3), were designed and synthesized by the reaction of Cu(NO₃)₂·3H₂O, CuCl₂·2H₂O and CuSO₄·5H₂O with a quinoline-derived Schiff base ligand, L1 or L2, prepared by the condensation of quinoline-8-carbaldehyde with 4-aminobenzoic acid methyl ester or 4-aminobenzoic acid ethyl ester (benzocaine). The efficient bindings of the C1-C3 complexes with human serum albumin (HSA) and calf thymus DNA (CT-DNA) were analyzed by spectroscopy and molecular docking. These complexes could significantly quench the fluorescence of HSA through the st

SUBMITTER: Hu K 

PROVIDER: S-EPMC6194498 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature