Recruitment for longitudinal, randomised pregnancy trials initiated preconception: lessons from the effects of aspirin in gestation and reproduction trial.

ABSTRACT:

Background

Recruitment into large, preconception randomised clinical trials (RCT) is challenging. We describe clinic and community-based preconception recruitment strategies for the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial and highlight approaches that were and were not successful. This longitudinal RCT was conducted at four major sites in the US. Eligible women had one to two prior pregnancy losses and were actively trying to become pregnant.

Methods

Provider/clinic and community-based outreach strategies were utilised, and the recruitment rate and costs of methods were assessed.

Results

A screening questionnaire was completed by 5485 women; 42.4% (n = 2323) screened were initially eligible, of whom 50.7% (n = 1228) were randomised. Provider/cli

SUBMITTER: Lesher LL 

PROVIDER: S-EPMC6194508 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature